Amakuru

Ku barwayi bafite umutima woroshye wa Cardiomyopathie (MDCM), ubwinshi bwa poroteyine C-reaction cyane (hs-CRP) bifitanye isano no kwiyongera kwa N-terminal ubwonko bwa natriuretic peptide (NT-proBNP) ku barwayi bafite umutima woroshye wa kardiomyopathie (MDCM) .), nubwo nta bimenyetso bifatika byerekana ingaruka ziteganijwe zijyanye nibisubizo byabarwayi.Ibisubizo byatangajwe mu kinyamakuru ESC Umutima Kunanirwa.
Isesengura ryisubiramo ry’abarwayi bafite umutima wiyongereye (DCM) hamwe n’igice cyo gusohora amashanyarazi kiri munsi ya 50% binjiye mu bitaro bya Fuwai i Beijing mu Bushinwa kuva mu Kuboza 2006 kugeza Ukwakira 2017.Abashakashatsi bashatse kugereranya biomarkers NT-proBNP na hs-CRP mu barwayi ba MDCM n’abarwayi ba DCM.Muri ubu bushakashatsi, MDCM yasobanuwe nkibumoso bwa ventricular end-diastolic diameter (LVEDDi) ya mm 33 / m2 cyangwa munsi yabagabo na 34 mm / m2 kubagore.
Abitabiriye bose hamwe 640 bashyizwe mu isesengura, muri bo 17% bashyizwe mu rwego rwo kugira MDCM naho 83% bashyizwe mu rwego rwo kugira DCM ku murongo fatizo.Muri rusange, 24.8% by'abitabiriye amahugurwa ni abagore.Ikigereranyo cyo hagati y’abarwayi cyari imyaka 49.
Ugereranije n'abitabiriye DCM, abarwayi ba MDCM bari bato, bafite umuvuduko ukabije w'amaraso, umubare munini wa diyabete, umubare muto wa tachycardia idafite imbaraga, igipimo kinini cy'umubiri, ndetse no kumara igihe gito mu bitaro. Kubijyanye na biomarkers yumutima, abarwayi bafite MDCM bari bafite igipimo cyo hasi cyane cya NT-proBNP ugereranije n’abarwayi bafite DCM (2203 pg / mL vs 1448 pg / mL; P <.001). Kubijyanye na biomarkers, abarwayi bafite MDCM bari bafite igipimo cyo hasi cyane cya NT-proBNP ugereranije n’abarwayi bafite umutima wa DCM (2203 pg / mL vs 1448 pg / mL; P <.001). Что касается сердечных биомареров, у манов с MDCM средний оровень NT-proBNP был значительно ниже по сравнению с шенентами с DCM (2203 пг / про провир 1448 пг / у соответственно) P <0,001) Ku bijyanye na biomarkers yumutima, abarwayi ba MDCM bari hasi cyane bivuze urwego rwa NT-proBNP ugereranije n’abarwayi ba DCM (2203 pg / mL na 1448 pg / mL; P <0.001).关于 心脏 生物 标志 物 与 与 DCM 患者 相比 ， MDCM 患者 的 NT-proBNP 水平 中 位数 显 着 降低 分别 3 2203 pg / mL 和 1448 pg / mL ； P <.001）。MDCM 患者 的 NT-proBNP 水平 中 位数 显 着 降低 分别 ， 与 2203 pg / mL 和 L0.0 pg / mL 和 L0.0 Что касается сердечных биомаркеров, у башов с MDCM средний оровень NT-proBNP был значительно ниже по сравнению с шенентами с DCM (2203 пг / ша и 1448 пг / у соответственно) P <0,001) Kubijyanye na biomarkers yumutima, bivuze ko urwego rwa NT-proBNP rwaragabanutse cyane kubarwayi ba MDCM ugereranije n’abarwayi ba DCM (2203 pg / mL na 1448 pg / mL; P <0.001).Ibinyuranye, bivuze ko urwego rwa hs-CRP rwabaye rwinshi mu barwayi ba MDCM kuruta mu barwayi ba DCM (3.09 mg / L na mg / L 2,79; P = 0.39).
Mu barwayi 282 bakurikiranwe na echocardiografi mu gihe cy’amezi 6 cyangwa arenga, abarwayi 7 barwaye MDCM (11.1%) barwaye DCM, mu gihe abarwayi 70 barwaye DCM (32.0%) basubiye muri MDCM, kimwe n’impinduka yagaragaye muri LVEDDi.
Abarwayi ba MDCM baseline bafite ibyago bike byo guhitanwa nimpfu zose, guhindurwa umutima, no kwandikirwa kunanirwa k'umutima ugereranije nabitabiriye DCM (igipimo cya hazard [aHR], 0,63; 95% CI, 0.43–0.93; P = 0.019).
Inzego zombi za hs-CRP na NT-proBNP zahujwe zigenga zifatanije nu ndunduro ihuriweho hamwe yose hamwe (hs-CRP, aHR, 1.07; 95% CI, 1.00-1.15 na NT-proBNP: aHR, 1.11, 95% CI, 1.02–1.22, p = 0.019).
Nyuma yo kugereranya amanota yerekana hagati ya MDCM na DCM, ihuriro riri murwego rwo hejuru rwa NT-proBNP hamwe n’iherezo ryahurijwe hamwe ryahuye n’ibyavuzwe mbere yo kugereranya abarwayi na DCM (RR, 1.83; 95% CI, 1.05–3.20; P = 0.034), ariko ntabwo ari mubarwayi barwaye MDCM (HR, 1.54, 95% CI, 0.76–3.11, P = 0.227).Ibinyuranye, urwego rwa hs-CRP rwari rugifitanye isano cyane no guhanura abarwayi bafite MDCM (RR 3.19; 95% CI 1.52–6.66; P = 0.002), ariko ntabwo ari kubarwayi bafite DCM (RR 1.04; 95% CI).0.61–1.79;p = 0.88).
Intambamyi y’ubushakashatsi ni uko phenotype y’abarwayi ishobora guhinduka mugihe cyo kuyikurikirana, nubwo umubare wabantu bongeye gusubiramo echocardiografiya wari muto cyane, bityo abahanuye impinduka za fenotipiki ntibasesenguwe.Byongeye kandi, kubera ubunini bw'icyitegererezo cy'abarwayi ba MDCM mu bushakashatsi, ibintu bishobora gutera urujijo ntabwo byahinduwe neza mu isesengura ryinshi.
Abanditsi b'ubushakashatsi bagize bati: "Baseline hs-CRP yajyanye n'ibisubizo byahujwe ku barwayi ba MDCM mbere na nyuma yo guhindura covariates, mu gihe NT-proBNP yari ifitanye isano gusa n'ibyavuye muri DCM".Ati: “Ubushakashatsi buracyakenewe kugira ngo hakorwe iperereza ku bahanura impinduka mu mikorere ya geometrike no mu mikorere y'umutima, cyane cyane ku barwayi barwaye MDCM, kugira ngo hashobore kubaho ibyiciro nyabyo.”
Kumenyekanisha: Nta numwe mubanditsi wubushakashatsi wavuze ko afitanye isano na biotech, farumasi, na / cyangwa ibigo by ibikoresho.
Feng J, Tian P, Liang L, n'abandi.Ibisubizo nibisobanuro byagaciro bya N-terminal pro-ubwonko natriuretic peptide na sensibilité nyinshi C-reaction proteine ​​yoroheje kandi yagutse yumutima.ESC kunanirwa k'umutima.Byatangajwe kumurongo 4 Werurwe 2022 doi: 10.1002 / ehf2.13864
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