Amakuru

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Gukura kw'amagufa kugaragara cyane mugihe cy'ubugimbi.Ubu bushakashatsi bwari bugamije gusobanura ingaruka z'umubiri w'ingimbi zubaka n'imbaraga ku bimenyetso by'amagufwa y’amagufwa hamwe no guhinduranya amagufwa kugira ngo bifashe kuzamura imikurire y'amagufwa mu gihe cy'ubugimbi n'ubwangavu no kwirinda ostéoporose.Kuva mu 2009 kugeza 2015, abangavu 277 (abahungu 125 n’abakobwa 152) bafite imyaka 10/11 na 14/15 bitabiriye ubushakashatsi.Ibipimo birimo fitness / indangagaciro z'umubiri (urugero, igipimo cy'imitsi, nibindi), imbaraga zo gufata, ubucucike bw'amagufwa (indangagaciro ya osteosonometry, OSI), hamwe n'ibimenyetso bya metabolism yo mu magufa (fosifata yo mu bwoko bwa alkaline fosifata n'ubwoko bwa I kolagen ihuza N) .peptide ya peptide).Isano nziza hagati yubunini bwumubiri / gufata imbaraga na OSI yabonetse mubakobwa bafite imyaka 10/11.Mu bahungu bafite imyaka 14/15, ingano yumubiri / gufata imbaraga zose zahujwe neza na OSI.Imihindagurikire yimitsi yumubiri yahujwe neza nimpinduka za OSI mubitsina byombi.Uburebure, igipimo cyimitsi yumubiri hamwe no gufata imbaraga kumyaka 10/11 yimyaka mubitsina byombi byari bifitanye isano rya bugufi na OSI (positif) hamwe nibimenyetso byamagufwa ya metabolisme (negative) kumyaka 14/15.Umubiri uhagije nyuma yimyaka 10-11 kumuhungu no kugeza kumyaka 10-11 kumukobwa birashobora kuba ingirakamaro mukwongera ubwinshi bwamagufwa.
Icyizere cy'ubuzima bwiza cyatanzwe n’umuryango w’ubuzima ku isi (OMS) mu 2001 nkigihe kingana nigihe umuntu ashobora kuyobora ubuzima bwiza wenyine mubuzima bwe bwa buri munsi.Mu Buyapani, ikinyuranyo hagati yubuzima buzira umuze nigihe cyo kubaho cyateganijwe kurenza imyaka 10.Niyo mpamvu, “Ihuriro ry’igihugu riharanira guteza imbere ubuzima mu kinyejana cya 21 (Ubuyapani Buzima 21)” ryashyizweho kugira ngo ubuzima bwiza bube3,4.Kugirango ubigereho, birakenewe gutinza abantu igihe cyo kubitaho.Indwara ya syndrome, intege nke na osteoporose5 nimpamvu nyamukuru zo kwivuza mubuyapani.Byongeye kandi, kurwanya syndrome de metabolike, umubyibuho ukabije mu bwana, intege nke na syndrome ya moteri ni ingamba zo gukumira ibikenewe kwitabwaho6.
Nkuko twese tubizi, imyitozo ngororamubiri isanzwe ningirakamaro kubuzima bwiza.Gukina siporo, sisitemu ya moteri, igizwe namagufa, ingingo n'imitsi, igomba kuba nziza.Kubera iyo mpamvu, Ishyirahamwe ry’imyororokere ry’Ubuyapani ryasobanuye “Syndrome de Motion” mu 2007 ko ari “ubudahangarwa bitewe n’indwara zifata imitsi kandi [aho usanga] hari ibyago byinshi byo gusaba ubuvuzi bw'igihe kirekire mu gihe kiri imbere” 7, kandi hakozwe ubushakashatsi ku ngamba zo gukumira kuva icyo gihe.hanyuma.Nyamara, ukurikije impapuro zera 2021, gusaza, kuvunika, hamwe nindwara ya musculoskeletal8 bikomeje kuba impamvu zitera ubuvuzi bukenewe mubuyapani, bingana na kimwe cya kane cyibikenewe byitaweho.
By'umwihariko, bivugwa ko osteoporose itera kuvunika yibasira 7.9% by'abagabo na 22.9% by'abagore barengeje imyaka 40 mu Buyapani9,10.Kumenya hakiri kare no kuvura bigaragara ko aribwo buryo bwingenzi bwo kwirinda ostéoporose.Isuzuma ry'ubucucike bw'amagufwa (BMD) ni ingenzi mu gutahura hakiri kare.Imbaraga ebyiri X-ray yakira (DXA) isanzwe ikoreshwa nkigipimo cyo gusuzuma amagufwa muburyo butandukanye bwa radiologiya.Icyakora, bivugwa ko kuvunika byagaragaye no muri BMD nyinshi, kandi mu 2000 Inama y’igihugu y’ubuzima (NIH) 11 y’ubwumvikane yasabye ko amagufwa yiyongera mu rwego rwo gusuzuma amagufwa.Ariko, gusuzuma ubuziranenge bwamagufwa bikomeje kuba ingorabahizi.
Uburyo bumwe bwo gusuzuma BMD ni ultrasound (ultrasound quantitative, QUS) 12,13,14,15.Ubushakashatsi bwerekanye kandi ko ibisubizo bya QUS na DXA bifitanye isano 16,17,18,19,20,21,22,23,24,25,26,27.Nyamara, QUS ntabwo itera, ntabwo ikoresha radio, kandi irashobora gukoreshwa mugupima abagore batwite nabana.Mubyongeyeho, ifite inyungu isobanutse kurenza DXA, ni ukuvuga ko ikurwaho.
Amagufwa yafashwe na osteoclasts agakorwa na osteoblasts.Ubucucike bw'amagufwa bugumaho niba metabolism igufwa ari ibisanzwe kandi hariho uburinganire hagati yo gufata amagufwa no gukora amagufwa.
Ibinyuranye, metabolism idasanzwe y'amagufwa itera BMD kugabanuka.Kubwibyo, kugirango hamenyekane hakiri kare osteoporose, ibimenyetso byerekana amagufwa ya metabolisme, ibyo bikaba ari ibimenyetso byigenga bifitanye isano na BMD, harimo ibimenyetso byerekana amagufwa no gufata amagufwa, bikoreshwa mugusuzuma metabolism yo mu Buyapani.Ikigeragezo cyo Kuvunika (FIT) gifite aho kirangirira cyo gukumira kuvunika byerekanaga ko BMD ari ikimenyetso cyerekana amagufwa aho kuba amagufwa 16,28.Muri ubu bushakashatsi, hapimwe ibimenyetso byerekana amagufwa yo mu magufa na byo byapimwe kugira ngo bige ku buryo bugaragara imbaraga za metabolism yo mu magufa.Harimo ibimenyetso byerekana amagufwa (ubwoko bwamagufwa ya alkaline fosifata, BAP) nibimenyetso byerekana amagufwa (guhuza N-terminal ubwoko bwa I collagen peptide, NTX).
Ubugimbi nubwangavu bwikura ryikura ryinshi (PHVA), mugihe imikurire yamagufwa yihuta kandi ubwinshi bwamagufwa (impinga yamagufwa, PBM) hashize imyaka 20.
Bumwe mu buryo bwo kwirinda osteoporose ni ukongera PBM.Ariko, kubera ko amakuru arambuye yo guhinduranya amagufwa mu ngimbi atazwi, nta bikorwa byihariye bishobora gutangwa ngo BMD yiyongere.
Kubwibyo, ubu bushakashatsi bwari bugamije gusobanura ingaruka ziterwa numubiri nimbaraga zumubiri kumagufwa yubunini bwamagufwa hamwe nibimenyetso bya skeletale mugihe cyubwangavu, mugihe imikurire yamagufa iba ikora cyane.
Ubu ni imyaka ine yiga cohort kuva mucyiciro cya gatanu cyamashuri abanza kugeza mucyiciro cya gatatu cyamashuri yisumbuye.
Abitabiriye amahugurwa barimo abahungu n’abakobwa bangavu bitabiriye ubushakashatsi bw’ubuzima bwa Iwaki Ubuzima bw’ibanze n’Amashuri yisumbuye mu cyiciro cya gatanu cy’amashuri abanza n’icyiciro cya gatatu cy’amashuri yisumbuye.
Amashuri ane abanza nayisumbuye yatoranijwe, aherereye mukarere ka Iwaki mumujyi wa Hirosaki mumajyaruguru yUbuyapani.Ubushakashatsi bwakozwe mu gihe cyizuba.
Kuva mu 2009 kugeza 2011, kwemerera abanyeshuri bo mu cyiciro cya 5 (imyaka 10/11) n'ababyeyi babo barabajijwe barapimwa.Mu masomo 395, abantu 361 bitabiriye ubushakashatsi, ni 91.4%.
Kuva mu 2013 kugeza 2015, kwemerera abanyeshuri bo mu mwaka wa gatatu w'amashuri yisumbuye (14/15 ans) n'ababyeyi babo barabajijwe barapimwa.Mu masomo 415, abantu 380 bitabiriye ubushakashatsi, ni 84.3%.
323 bitabiriye amahugurwa barimo abantu bafite amateka y’indwara zifata umutima, diyabete, dyslipidemiya, cyangwa hypertension, abantu bafata imiti, abantu bafite amateka y’imvune, abantu bafite amateka y’imvune ya calcane, n’abantu bafite indangagaciro zibuze mu isesengura.Ukuyemo.Abangavu 277 (abahungu 125 n’abakobwa 152) bashyizwe mu isesengura.
Ibice bigize ubushakashatsi birimo ibibazo, gupima ubwinshi bwamagufwa, gupima amaraso (ibimenyetso byerekana amagufwa ya metabolisme), hamwe no gupima fitness.Ubushakashatsi bwakozwe muminsi 1 yishuri ryibanze niminsi 1-2 yishuri ryisumbuye.Iperereza ryamaze iminsi 5.
Ikibazo cyatanzwe mbere yo kwiyuzuza.Abitabiriye amahugurwa basabwe kuzuza ibibazo hamwe n'ababyeyi babo cyangwa abarezi babo, kandi ibibazo byakusanyirijwe ku munsi wo gupimwa.Impuguke enye z’ubuzima rusange zasuzumye ibisubizo maze zigisha inama abana cyangwa ababyeyi babo niba hari ikibazo bafite.Ibibazo byabajijwe birimo imyaka, igitsina, amateka yubuvuzi, amateka yubuvuzi, nubu imiti.
Mu rwego rwo gusuzuma umubiri ku munsi w’ubushakashatsi, hafashwe ibipimo by'uburebure hamwe n'ibigize umubiri.
Ibipimo bigize umubiri birimo uburemere bwumubiri, ijanisha ryibinure byumubiri (% ibinure), nijanisha ryumubiri (% imitsi).Ibipimo byafashwe hifashishijwe isesengura ry'umubiri ushingiye ku buryo bwa bioimpedance (TBF-110; Tanita Corporation, Tokiyo).Igikoresho gikoresha imirongo myinshi 5 kHz, 50 kHz, 250 kHz na 500 kHz kandi yakoreshejwe mubushakashatsi bwinshi bwabantu bakuru 29,30,31.Igikoresho cyagenewe gupima abitabiriye byibura cm 110 z'uburebure na 6 ans cyangwa irenga.
BMD nikintu cyingenzi kigize imbaraga zamagufwa.Isuzuma rya BMD ryakozwe na ECUS hakoreshejwe igikoresho cya ultrasound igufwa (AOS-100NW; Aloka Co., Ltd., Tokiyo, Ubuyapani).Ikibanza cyo gupimisha cyari calcane, cyasuzumwe hifashishijwe indangagaciro ya Osteo Sono-Isuzuma (OSI).Iki gikoresho gipima umuvuduko wijwi (SOS) nicyerekezo cyohereza (TI), hanyuma bikoreshwa mukubara OSI.SOS ikoreshwa mugupima kubara hamwe nubucucike bwamagufwa 34,35 naho TI ikoreshwa mugupima kwiyongera kwa ultrasound yagutse, indangagaciro yo gusuzuma ubuziranenge bwamagufa12,15.OSI ibarwa ukoresheje formula ikurikira:
Rero kwerekana ibiranga SOS na TI.Kubwibyo, OSI ifatwa nkimwe mu ndangagaciro zerekana isi yose mugusuzuma amagufwa acoustic.
Kugirango dusuzume imbaraga z'imitsi, twakoresheje imbaraga zo gufata, zitekerezwa kwerekana imbaraga z'umubiri wose 37,38.Dukurikiza uburyo bwa "Ikizamini gishya cyimyitozo ngororamubiri" 39 ya Biro ya Siporo ya Minisiteri y'Uburezi, Umuco, Siporo, Ubumenyi n'Ikoranabuhanga.
Smedley gufata dinometero (TKK 5401; Takei Scientific Instruments Co., Ltd., Niigata, Ubuyapani).Ikoreshwa mugupima imbaraga zo gufata no guhindura ubugari bwa grip kuburyo hafi ya interfalangeal ihuza urutoki rwimpeta ihindagurika 90 °.Iyo upimye, umwanya w'igihagararo uhagaze n'amaguru arambuye, umwambi wo gupima intoki ukomeza kureba imbere, ibitugu byimurirwa gato ku mpande, bidakora ku mubiri.Abitabiriye amahugurwa basabwe gufata dinometero nimbaraga zose uko bahumeka.Mugihe cyo gupima, abitabiriye amahugurwa basabwe kugumya gufata moteri ya dinometero mu gihe bakomeza igihagararo cyibanze.Buri kiganza gipimwa kabiri, kandi amaboko n'ibumoso n'iburyo byapimwe ubundi kugirango ubone agaciro keza.
Mu gitondo cya kare ku gifu cyuzuye, amaraso yakusanyirijwe mu bana bo mu cyiciro cya gatatu cy'amashuri yisumbuye, hanyuma isuzuma ry'amaraso ryashyikirizwa LSI Medience Co., Ltd. Isosiyete yapimye kandi amagufwa (BAP) hamwe n'amagufwa akoresheje CLEIA ( enzymatique immunochemiluminescent assay) uburyo.kubimenyetso bya resorption (NTX).
Ingamba zabonetse mu cyiciro cya gatanu cy'amashuri abanza n'icyiciro cya gatatu cy'amashuri yisumbuye yagereranijwe hakoreshejwe t-test zombi.
Kugirango ushakishe ibintu bishobora gutera urujijo, isano iri hagati ya OSI kuri buri cyiciro nuburebure, ijanisha ryibinure byumubiri, ijanisha ryimitsi, nimbaraga zo gufata byemejwe hakoreshejwe coefficient igice.Ku banyeshuri bo mu cyiciro cya gatatu cy'amashuri yisumbuye, ihuriro hagati ya OSI, BAP, na NTX ryemejwe hakoreshejwe coefficient igice.
Kugira ngo hakorwe iperereza ku ngaruka z’imihindagurikire y’umubiri n’imbaraga kuva mu cyiciro cya gatanu cy’amashuri abanza kugeza mu cyiciro cya gatatu cy’amashuri yisumbuye yisumbuye kuri OSI, hasuzumwe impinduka z’amavuta y’umubiri, ubwinshi bwimitsi, nimbaraga zifatika zijyanye nimpinduka muri OSI.Koresha isesengura ryinshi.Muri iri sesengura, impinduka muri OSI yakoreshejwe nkibihinduka intego kandi impinduka muri buri element yakoreshejwe nkibihinduka bisobanura.
Isesengura ryisubiramo ryakoreshejwe mukubara ibipimo bitandukanijwe hamwe 95% intera yicyizere cyo kugereranya isano iri hagati yimyitozo ngororamubiri mu cyiciro cya gatanu cy’amashuri abanza na metabolism yo mu magufa (OSI, BAP na NTX) mu cyiciro cya gatatu cy'amashuri yisumbuye.
Uburebure, ibinure byumubiri, ijanisha ryimitsi, hamwe nimbaraga zo gufata byakoreshejwe nkibipimo byerekana imyitozo ngororamubiri / ubuziranenge kubanyeshuri bo mucyiciro cya gatanu cyibanze, buri kimwe muri byo cyakoreshwaga mu gushyira abanyeshuri mu matsinda mato, ayisumbuye, na tertile.
Porogaramu ya SPSS 16.0J (SPSS Inc, Chicago, IL, Amerika) yakoreshejwe mu gusesengura imibare kandi agaciro ka p <0.05 byafatwaga nk’imibare ifatika.
Intego y’ubushakashatsi, uburenganzira bwo kuva mu bushakashatsi igihe icyo ari cyo cyose, hamwe n’imikorere yo gucunga amakuru (harimo n’ibanga ry’amakuru no kutamenyekanisha amakuru) yasobanuriwe ku buryo burambuye abitabiriye amahugurwa bose, kandi uruhushya rwanditse rwabonetse ku bitabiriye amahugurwa ubwabo cyangwa ku babyeyi babo. ./ abarezi.
Ubushakashatsi bw’ubuzima bw’Amashuri abanza n’ayisumbuye Iwaki bwemejwe n’ikigo cy’isuzuma ry’ubuvuzi cya kaminuza ya Hirosaki (kwemeza nomero 2009-048, 2010-084, 2011-111, 2013-339, 2014-060 na 2015).-075).
Ubu bushakashatsi bwanditswe mu bitaro bya kaminuza by’ubuvuzi (UMIN-CTR, https://www.umin.ac.jp; izina ry'ikizamini: Ikizamini cy’ubuvuzi cya Iwaki Guteza imbere Ubuzima; na ID UMIN000040459).
Mu bahungu, ibipimo byose byiyongereye ku buryo bugaragara, usibye ibinure%, naho mu bakobwa, ibipimo byose byiyongereye ku buryo bugaragara.Mu mwaka wa gatatu w'amashuri yisumbuye, indangagaciro zerekana amagufwa ya metabolism mu bahungu nazo zari hejuru cyane ugereranije n'abakobwa, byagaragazaga ko metabolism yo mu magufwa mu bahungu muri iki gihe yakoraga cyane kurusha abakobwa.
Ku bakobwa bo mu cyiciro cya gatanu, habonetse isano nziza hagati yubunini bwumubiri / gufata imbaraga na OSI.Ariko, iyi myumvire ntiyagaragaye mubahungu.
Mu cyiciro cya gatatu abahungu, ingano yumubiri / gufata imbaraga zose zahujwe neza na OSI kandi zifitanye isano na NTX na / BAP.Ibinyuranye, iyi myumvire ntiyagaragaye cyane mubakobwa.
Hariho impinduka zikomeye mubibazo bya OSI yo hejuru mubanyeshuri bo mucyiciro cya gatatu n'icya gatanu muburebure bwo hejuru, ijanisha ryibinure, ijanisha ryimitsi, hamwe nitsinda rifata imbaraga.
Byongeye kandi, uburebure buri hejuru, ijanisha ryibinure byumubiri, ijanisha ryimitsi, hamwe no gufata imbaraga mubiciro bya gatanu byabagabo nabagore bakunze kugabanya cyane itandukaniro riri hagati y amanota ya BAP na NTX mumashuri ya cyenda.
Kongera gushiraho no gusubiza amagufwa bibaho mubuzima bwose.Ibi bikorwa byo guhinduranya amagufwa bigengwa na hormone zitandukanye40,41,42,43,44,45,46 na cytokine.Hariho impinga ebyiri mu mikurire yamagufa: gukura kwambere mbere yimyaka 5 no gukura kwa kabiri mugihe cyubwangavu.Mu cyiciro cya kabiri cyo gukura, imikurire ya axe ndende yamagufa yararangiye, umurongo wa epiphyseal urafunga, igufwa rya trabecular rihinduka ryinshi, kandi BMD iratera imbere.Abitabiriye ubu bushakashatsi bari mu gihe cy’iterambere ry’imiterere y’imibonano mpuzabitsina ya kabiri, igihe isohoka ry’imisemburo y’imibonano mpuzabitsina ryakoraga kandi ibintu bigira ingaruka ku mikorere y’amagufwa.Rauchenzauner n'abandi.47Icyakora, nta bushakashatsi bwakozwe kugira ngo bukore iperereza kuri ibyo bintu mu rubyiruko rw'Abayapani.Hariho kandi raporo nkeya cyane kubyerekeranye nibimenyetso bya DXA bijyanye nibintu bya metabolisme yamagufwa mubyangavu b'Abayapani.Imwe mu mpamvu zibitera ni ukudashaka kw'ababyeyi n'abarezi kwemerera ibizamini byibasiye abana babo, nko gukusanya amaraso n'imirasire, nta kwisuzumisha cyangwa kuvurwa.
Ku bakobwa bo mu cyiciro cya gatanu, habonetse isano nziza hagati yubunini bwumubiri / gufata imbaraga na OSI.Ariko, iyi myumvire ntiyagaragaye mubahungu.Ibi birerekana ko iterambere ryubunini bwumubiri mugihe cyubwangavu bigira ingaruka kuri OSI mubakobwa.
Imiterere yumubiri / gufata imbaraga zose zahujwe neza na OSI mubahungu bo mucyiciro cya gatatu.Ibinyuranye na byo, iyi myumvire ntiyagaragaye cyane mu bakobwa, aho impinduka gusa ku ijanisha ryimitsi no gufata imbaraga zifitanye isano na OSI.Imihindagurikire yimitsi yumubiri yahujwe neza nimpinduka muri OSI hagati yimibonano mpuzabitsina.Ibisubizo byerekana ko mubahungu, kwiyongera k'ubunini bw'umubiri / imbaraga z'imitsi kuva mu cyiciro cya 5 kugeza ku cya 3 bigira ingaruka kuri OSI.
Uburebure, igipimo cyumubiri-imitsi, hamwe nimbaraga zo gufata mucyiciro cya gatanu cyamashuri abanza byari bifitanye isano ryiza na indangagaciro ya OSI kandi bifitanye isano ribi cyane ningamba zo guhinduranya amagufwa mu cyiciro cya gatatu cy'amashuri yisumbuye.Aya makuru yerekana ko iterambere ryubunini bwumubiri (uburebure nuburinganire bwumubiri-ku mubiri) hamwe no gufata imbaraga mubyangavu hakiri kare bigira ingaruka kuri OSI na metabolism.
Imyaka ya kabiri yo gukura kwinshi (PHVA) mu kiyapani yagaragaye ku myaka 13 ku bahungu na 11 ku bakobwa, hamwe no gukura vuba mu bahungu49.Ku myaka 17 mu bahungu na 15 ans mu bakobwa, umurongo wa epiphyseal utangira gufunga, BMD ikiyongera yerekeza kuri BMD.Urebye aya mateka n'ibisubizo by'ubu bushakashatsi, turakeka ko kongera uburebure, ubwinshi bw'imitsi, n'imbaraga z'imitsi ku bakobwa kugeza mu cyiciro cya gatanu ari ngombwa mu kongera BMD.
Ubushakashatsi bwibanze ku bana bato ningimbi bakura bwerekanye ko ibimenyetso byerekana amagufwa hamwe no gukora amagufwa amaherezo byiyongera50.Ibi birashobora kwerekana amagufwa akomeye.
Isano iri hagati yo guhinduranya amagufwa na BMD yagiye ikorerwa ubushakashatsi bwinshi kubantu bakuru 51,52.Nubwo raporo zimwe53, 54, 55, 56 zigaragaza inzira zitandukanye kubagabo, isubiramo ryibyagaragaye mbere rishobora kuvunagurwa muburyo bukurikira: "Ibimenyetso byerekana metabolisme yamagufwa byiyongera mugihe cyo gukura, hanyuma bikagabanuka kandi ntibihinduka kugeza kumyaka 40, gusaza. ”.
Mu Buyapani, BAP indangagaciro ni 3.7–20.9 µg / L kubagabo bazima na 2.9–14.5 µg / L kubagore bafite ubuzima bwiza mbere yo gucura.Indangagaciro za NTX ni 9.5-17.7 nmol BCE / L kubagabo bazima na 7.5-16.5 nmol BCE / L kubagore bafite ubuzima bwiza mbere yo gucura.Ugereranije nizo ndangagaciro zerekana mubushakashatsi bwacu, ibipimo byombi byateye imbere mubanyeshuri bo mucyiciro cya gatatu cy'amashuri yisumbuye, byagaragaye cyane mubahungu.Ibi byerekana ibikorwa bya metabolisme yamagufa mubanyeshuri bo mucyiciro cya gatatu, cyane cyane abahungu.Impamvu yo gutandukanya uburinganire irashobora kuba nuko abahungu bo mucyiciro cya 3 bakiri mucyiciro cyo gukura kandi umurongo wa epiphyseal utarafunga, mugihe mubakobwa muriki gihe umurongo wa epiphyseal wegereje gusozwa.Ni ukuvuga, abahungu bo mu cyiciro cya gatatu baracyatera imbere kandi bafite imikurire igaragara, mugihe abakobwa barangije igihe cyo gukura kwa skeletale kandi bakagera kumurongo wo gukura.Imigendekere yibimenyetso byamagufwa yabonetse muri ubu bushakashatsi ihuye nimyaka yo kwiyongera kwinshi mubatuye mubuyapani.
Byongeye kandi, ibyavuye muri ubu bushakashatsi byagaragaje ko abanyeshuri bo mu cyiciro cya gatanu cy’amashuri abanza bafite umubiri n’imbaraga zikomeye bafite imyaka mike ku mpinga ya metabolism.
Ariko, imbogamizi yubu bushakashatsi nuko ingaruka zimihango zitigeze zitaweho.Kubera ko amagufwa ya metabolism aterwa na hormone zo mu mibonano mpuzabitsina, ubushakashatsi buzaza bukeneye gukora ubushakashatsi ku ngaruka zimihango.